Sunday, May 24, 2009

HIV Vaccine Turns Muscle into Antibody Factories

Nine macaques have been protected against the monkey version of HIV with a novel vaccine that sidesteps the monkey immune system. Instead, the vaccine turns monkey muscles into factories for churning out antibodies.
Researchers injected the monkeys' muscles with a harmless virus carrying genes for making immunoadhesins, antibody-like molecules pre-selected to attack SIV.
The viruses put the genes into the nuclei of muscle cells, which produce antibodies that combat HIV, potentially indefinitely.

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